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PM H-Regulator® – Safe, Effective Menopause Relief
Menopause isn’t a time of life that many women look forward to. Hot flushes, sleepless nights, mood swings, sore breasts, vaginal dryness – these are just some of the major symptoms that confront many women while undergoing ‘change of life.’ But do they need to? The weight of research now suggests that there are a number of viable, natural, scientifically-validated alternative treatments available for women during menopause to help them regain control of their hormones. What’s more, they actually work.
Women have been aware of the benefits of hormone replacement therapy, or HRT, during menopause for many years now. Essentially, as menopause sets in, the ovaries begin to function erratically. A woman’s monthly cycle becomes less predictable, periods begin to skip and, eventually cease altogether as the ovaries effectively cease to produce progesterone and the oestrogens, oestradiol and oestriol.  Because of the lowered levels of oestrogen in the body during menopause, a hormonal imbalance results, which consequently leads to the unwanted symptoms associated with ‘change of life.’ Therefore, simply enough, hormone replacement therapy endeavours to restore hormonal balance by providing menopausal women with pharmaceutical preparations containing the oestrogen they no longer produce, with some preparations also containing the hormone progesterone.  However, despite being effective, long-term treatment with oestrogens may be limited due to its potentially negative health effects: it has repeatedly been associated with an increased risk of breast cancer in women [2, 3], an increased risk of endometrial adenocarcinoma and endometrial hyperplasia.
Accordingly, current treatment guidelines indicate that HRT should be used only in the short term for moderate-to-severe symptoms, with the lowest effective dose for treatment.  As a result, a number of complementary and alternative therapies for PMS and menopause have found favour among millions of women around the world. The therapeutic use of soy isoflavones has garnered particular interest.
Isoflavones are a naturally occurring type of phytoestrogen, and structurally resemble endogenous oestrogens. These compounds can bind directly to oestrogen receptors, and can act as selective oestrogen receptor modulators (SERMs), essentially meaning that they may mediate oestrogenic activity in certain parts of the body, but not in others.  Recent findings have shown that by acting oestrogenically, isoflavones are effective in reducing the severity and occurrence of menopausal symptoms such as hot flushes, increased perspiration and night sweats. [7-10] More importantly, isoflavones do not appear to mediate the negative reproductive effects experienced with chronic oestrogen therapy, and do not seem to increase the risk of endometrial or breast cancer. [11, 12] That is, the use of soy isoflavones for menopausal relief may provide women with all the relief of conventional oestrogen HRT, without any of the unwanted side effects.
Chasteberry has also been lauded as an effective medicament for women’s health, with clinical trials having demonstrated that treatment with chasteberry can provide relief to women suffering from the symptoms of menopause-related distress. In several double-blind, randomised, placebo-controlled studies [13-15], chasteberry has mediated significant improvements in irritability, mood alteration, anger and headache in women relative to placebo controls. Studies have also shown chasteberry to provide relief from the common female symptoms of bloating, general oedema and mastalgia (breast tenderness), providing evidence for its beneficial regulatory effect on hormonal levels prior to, during and post menopause.  It is also indicated for irregularities of the menstrual cycle.
PMH-Regulator® and menopause
By combining chasteberry and soy isoflavones into a single formula, PMH-Regulator® has taken a unique approach to women’s health. While both ingredients are clinically proven to be effective, to date PMH-Regulator® is the only formula available that uses scientifically validated doses of both. Chasteberry is provided to help treat the symptoms of PMS and menopause, as well as for its known ability to help stabilise the hormonal cycle. Soy isoflavones are provided to treat the underlying cause of the negative symptoms associated with menopause – lack of oestrogen. That is, PMH-Regulator® targets the symptoms and the cause of the unpleasant experiences associated with menopause. What’s more, it’s safe, natural and proven.
In light of the health warnings against conventional HRT, the time to switch to an effective, minimum-risk medication for the management of menopause and general female health could not be better.
- Cheung AM, Chaudhry R, Kapral M, Jackevicius C, Robinson G: Perimenopausal and Postmenopausal Health. BMC Womens Health 2004, 4 Suppl 1:S23.
- Ewertz M, Mellemkjaer L, Poulsen AH, Friis S, Sorensen HT, Pedersen L, McLaughlin JK, Olsen JH: Hormone use for menopausal symptoms and risk of breast cancer. A Danish cohort study. Br J Cancer 2005, 92(7):1293-1297.
- Bakken K, Alsaker E, Eggen AE, Lund E: [Estrogen replacement therapy and breast cancer]. Tidsskr Nor Laegeforen 2005, 125(3):282-285.
- Rueda BR ZL: Loss of cables is associated with development of endometrial hyperplasia and cancer. International Journal of Gynaecological Cancer 2005, 15.
- U.SPreventativeServicesTaskForce: Hormone therapy for the prevention of chronic conditions in postmenopausal women: Recommendations from the U.S. Preventative Services Task Force. Anals of Internal Medicine 2005, 142(10):855-860.
- Mueller SO, Simon S, Chae K, Metzler M, Korach KS: Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci 2004, 80(1):14-25.
- Nahas EA, Nahas-Neto J, Orsatti FL, Carvalho EP, Oliveira ML, Dias R: Efficacy and safety of a soy isoflavone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas 2007, 58(3):249-258.
- Faure ED, Chantre P, Mares P: Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2002, 9(5):329-334.
- Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL, Lamia CA: Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000, 7(4):236-242.
- Khaodhiar L, Ricciotti HA, Li L, Pan W, Schickel M, Zhou J, Blackburn GL: Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women. Menopause 2008, 15(1):125-132.
- Finking G, Hess B, Hanke H: The value of phytoestrogens as a possible therapeutic option in postmenopausal women with coronary heart disease. J Obstet Gynaecol 1999, 19(5):455-459.
- Phipps WR, Duncan AM, Kurzer MS: Isoflavones and postmenopausal women: a critical review. Treat Endocrinol 2002, 1(5):293-311.
- Schellenberg R: Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ 2001, 322(7279):134-137.
- Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A: Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet 2000, 264(3):150-153.
- Loch EG, Selle H, Boblitz N: Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000, 9(3):315-320.
- Huddleston M, Jackson EA: Is an extract of the fruit of agnus castus (chaste tree or chasteberry) effective for prevention of symptoms of premenstrual syndrome (PMS)? J Fam Pract 2001, 50(4):298.
- Anthony MS, Clarkson TB, Hughes CL, Jr., Morgan TM, Burke GL: Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr 1996, 126(1):43-50.
- Kapiotis S, Hermann M, Held I, Seelos C, Ehringer H, Gmeiner BM: Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler Thromb Vasc Biol 1997, 17(11):2868-2874.
- Kirk EA, Sutherland P, Wang SA, Chait A, LeBoeuf RC: Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr 1998, 128(6):954-959.